Sahar Keshvari


Dr Sahar Keshvari’s main research interest is to investigate the role of macrophages in metabolic disorders including acute and chronic liver diseases, obesity and type 2 diabetes.

Sahar’s interest in metabolic disorders started during her PhD studies, where she performed research under the supervision of Prof Whitehead on characterisation of two receptors for adiponectin. She was awarded her PhD in September 2016 and received the “2016 Dean’s Award for Outstanding Higher Degree by Research Theses”. 

 Sahar joined Macrophage biology group in March 2019 to investigate the beneficial effect of macrophage colony stimulating factor (CSF1) as a potential treatment to reverse liver fibrosis and promote liver regeneration. Sahar is also investigating the role of macrophages and potential applications of CSF1 in metabolic regulation in fat and endocrine system including pancreas.

In 2017, Sahar was awarded a Research Program grant from Diabetes Australia —the national body for people affected by all types of diabetes. In 2021 she was awarded a two year Australian Liver Foundation Pauline Hall Research Fellowship to investigate the use of CSF1 to enhance the function of donor livers before transplant. 

In 2023 she was awarded an Emerging Leadership Investigator Grant from the NH&MRC to develop her own independent research focus




Hume, David A; Teakle, Ngari; Keshvari, Sahar; Irvine, Katharine M

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development (Journal Article)

In: J Leukoc Biol, 2023, ISSN: 1938-3673.

(Abstract | Links | BibTeX)

Sehgal, Anuj; Carter-Cusack, Dylan; Keshvari, Sahar; Patkar, Omkar; Huang, Stephen; Summers, Kim M; Hume, David A; Irvine, Katharine M

Intraperitoneal transfer of wild-type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis (Journal Article)

In: Eur J Immunol, pp. e2250312, 2023, ISSN: 1521-4141.

(Abstract | Links | BibTeX)

Summers, Kim M; Bush, Stephen J; Davis, Margaret R; Hume, David A; Keshvari, Sahar; West, Jennifer A

Fibrillin-1 and asprosin, novel players in metabolic syndrome (Journal Article)

In: Mol Genet Metab, vol. 138, no. 1, pp. 106979, 2023, ISSN: 1096-7206.

(Abstract | Links | BibTeX)

Ferrari-Cestari, Michelle; Okano, Satomi; Patel, Preya J; Horsfall, Leigh U; Keshvari, Sahar; Hume, David A; Williams, Suzanne; Russell, Anthony; Powell, Elizabeth E; Irvine, Katharine M

Serum CC-Chemokine Ligand 2 Is Associated with Visceral Adiposity but Not Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease (Journal Article)

In: Dig Dis, vol. 41, no. 3, pp. 439–446, 2023, ISSN: 1421-9875.

(Abstract | Links | BibTeX)


Hume, David A; Batoon, Lena; Sehgal, Anuj; Keshvari, Sahar; Irvine, Katharine M

CSF1R as a Therapeutic Target in Bone Diseases: Obvious but Not so Simple (Journal Article)

In: Curr Osteoporos Rep, vol. 20, no. 6, pp. 516–531, 2022, ISSN: 1544-2241.

(Abstract | Links | BibTeX)

Stables, Jennifer; Green, Emma K; Sehgal, Anuj; Patkar, Omkar L; Keshvari, Sahar; Taylor, Isis; Ashcroft, Maisie E; Grabert, Kathleen; Wollscheid-Lengeling, Evi; Szymkowiak, Stefan; McColl, Barry W; Adamson, Antony; Humphreys, Neil E; Mueller, Werner; Starobova, Hana; Vetter, Irina; Shabestari, Sepideh Kiani; Blurton-Jones, Matthew M; Summers, Kim M; Irvine, Katharine M; Pridans, Clare; Hume, David A

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling (Journal Article)

In: Development, vol. 149, no. 8, 2022, ISSN: 1477-9129.

(Abstract | Links | BibTeX)

Keshvari, Sahar; Genz, Berit; Teakle, Ngari; Caruso, Melanie; Cestari, Michelle F; Patkar, Omkar L; Tse, Brian W C; Sokolowski, Kamil A; Ebersbach, Hilmar; Jascur, Julia; MacDonald, Kelli P A; Miller, Gregory; Ramm, Grant A; Pettit, Allison R; Clouston, Andrew D; Powell, Elizabeth E; Hume, David A; Irvine, Katharine M

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease (Journal Article)

In: Dis Model Mech, 2022, ISSN: 1754-8411.

(Abstract | Links | BibTeX)


Keshvari, Sahar; Caruso, Melanie; Teakle, Ngari; Batoon, Lena; Sehgal, Anuj; Patkar, Omkar L.; Ferrari-Cestari, Michelle; Snell, Cameron E.; Chen, Chen; Stevenson, Alex; Davis, Felicity M.; Bush, Stephen J.; Pridans, Clare; Summers, Kim M.; Pettit, Allison R.; Irvine, Katharine M.; Hume, David A.

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation (Journal Article)

In: PLOS Genetics, vol. 17, no. 6, pp. e1009605, 2021, ISSN: 1553-7404.

(Abstract | Links | BibTeX)

Hume, David A.; Caruso, Melanie; Keshvari, Sahar; Patkar, Omkar L.; Sehgal, Anuj; Bush, Stephen J.; Summers, Kim M.; Pridans, Clare; Irvine, Katharine M.

The Mononuclear Phagocyte System of the Rat (Journal Article)

In: The Journal of Immunology, vol. 206, no. 10, pp. 2251–2263, 2021, ISSN: 0022-1767, 1550-6606.

(Links | BibTeX)

Keshvari, Sahar; Caruso, Melanie; Teakle, Ngari; Batoon, Lena; Sehgal, Anuj; Patkar, Omkar L; Ferrari-Cestari, Michelle; Snell, Cameron E; Chen, Chen; Stevenson, Alex; Davis, Felicity M; Bush, Stephen J; Pridans, Clare; Summers, Kim M; Pettit, Allison R; Irvine, Katharine M; Hume, David A

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation (Journal Article)

In: PLOS Genetics, vol. 17, no. 6, pp. e1009605, 2021, ISSN: 1553-7404, (Publisher: Public Library of Science).

(Abstract | Links | BibTeX)

Patkar, O. L.; Caruso, M.; Teakle, N.; Keshvari, S.; Bush, S. J.; Pridans, C.; Belmer, A.; Summers, K. M.; Irvine, K. M.; Hume, D. A.

Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations (Journal Article)

In: Neurobiology of Disease, vol. 151, 2021, ISSN: 09699961, (Publisher: Academic Press Inc.).

(Abstract | Links | BibTeX)


Irvine, Katharine M.; Caruso, Melanie; Cestari, Michelle Ferrari; Davis, Gemma M.; Keshvari, Sahar; Sehgal, Anuj; Pridans, Clare; Hume, David A.

Analysis of the impact of CSF‐1 administration in adult rats using a novel textitCsf1r ‐mApple reporter gene (Journal Article)

In: Journal of Leukocyte Biology, vol. 107, no. 2, pp. 221–235, 2020, ISSN: 0741-5400, 1938-3673.

(Links | BibTeX)

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