Sahar Keshvari

Biography

Dr Sahar Keshvari’s main research interest is to investigate the role of macrophages in metabolic disorders including acute and chronic liver diseases, obesity and type 2 diabetes.

Sahar’s interest in metabolic disorders started during her PhD studies, where she performed research under the supervision of Prof Whitehead on characterisation of two receptors for adiponectin. She was awarded her PhD in September 2016 and received the “2016 Dean’s Award for Outstanding Higher Degree by Research Theses”. 

 Sahar joined Macrophage biology group in March 2019 to investigate the beneficial effect of macrophage colony stimulating factor (CSF1) as a potential treatment to reverse liver fibrosis and promote liver regeneration. Sahar is also investigating the role of macrophages and potential applications of CSF1 in metabolic regulation in fat and endocrine system including pancreas.

In 2017, Sahar was awarded a Research Program grant from Diabetes Australia —the national body for people affected by all types of diabetes. In 2021 she was awarded a two year Australian Liver Foundation Pauline Hall Research Fellowship to investigate the use of CSF1 to enhance the function of donor livers before transplant. 

SaharKeshvari

Publications:

2022

Stables, Jennifer; Green, Emma K; Sehgal, Anuj; Patkar, Omkar L; Keshvari, Sahar; Taylor, Isis; Ashcroft, Maisie E; Grabert, Kathleen; Wollscheid-Lengeling, Evi; Szymkowiak, Stefan; McColl, Barry W; Adamson, Antony; Humphreys, Neil E; Mueller, Werner; Starobova, Hana; Vetter, Irina; Shabestari, Sepideh Kiani; Blurton-Jones, Matthew M; Summers, Kim M; Irvine, Katharine M; Pridans, Clare; Hume, David A

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling (Journal Article)

In: Development, vol. 149, no. 8, 2022, ISSN: 1477-9129.

(Abstract | Links | BibTeX | Altmetric)

Keshvari, Sahar; Genz, Berit; Teakle, Ngari; Caruso, Melanie; Cestari, Michelle F; Patkar, Omkar L; Tse, Brian W C; Sokolowski, Kamil A; Ebersbach, Hilmar; Jascur, Julia; MacDonald, Kelli P A; Miller, Gregory; Ramm, Grant A; Pettit, Allison R; Clouston, Andrew D; Powell, Elizabeth E; Hume, David A; Irvine, Katharine M

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease (Journal Article)

In: Dis Model Mech, 2022, ISSN: 1754-8411.

(Abstract | Links | BibTeX | Altmetric)

2021

Keshvari, Sahar; Caruso, Melanie; Teakle, Ngari; Batoon, Lena; Sehgal, Anuj; Patkar, Omkar L.; Ferrari-Cestari, Michelle; Snell, Cameron E.; Chen, Chen; Stevenson, Alex; Davis, Felicity M.; Bush, Stephen J.; Pridans, Clare; Summers, Kim M.; Pettit, Allison R.; Irvine, Katharine M.; Hume, David A.

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation (Journal Article)

In: PLOS Genetics, vol. 17, no. 6, pp. e1009605, 2021, ISSN: 1553-7404.

(Abstract | Links | BibTeX | Altmetric)

Hume, David A.; Caruso, Melanie; Keshvari, Sahar; Patkar, Omkar L.; Sehgal, Anuj; Bush, Stephen J.; Summers, Kim M.; Pridans, Clare; Irvine, Katharine M.

The Mononuclear Phagocyte System of the Rat (Journal Article)

In: The Journal of Immunology, vol. 206, no. 10, pp. 2251–2263, 2021, ISSN: 0022-1767, 1550-6606.

(Links | BibTeX | Altmetric)

Keshvari, Sahar; Caruso, Melanie; Teakle, Ngari; Batoon, Lena; Sehgal, Anuj; Patkar, Omkar L; Ferrari-Cestari, Michelle; Snell, Cameron E; Chen, Chen; Stevenson, Alex; Davis, Felicity M; Bush, Stephen J; Pridans, Clare; Summers, Kim M; Pettit, Allison R; Irvine, Katharine M; Hume, David A

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation (Journal Article)

In: PLOS Genetics, vol. 17, no. 6, pp. e1009605, 2021, ISSN: 1553-7404, (Publisher: Public Library of Science).

(Abstract | Links | BibTeX | Altmetric)

Patkar, O. L.; Caruso, M.; Teakle, N.; Keshvari, S.; Bush, S. J.; Pridans, C.; Belmer, A.; Summers, K. M.; Irvine, K. M.; Hume, D. A.

Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations (Journal Article)

In: Neurobiology of Disease, vol. 151, 2021, ISSN: 09699961, (Publisher: Academic Press Inc.).

(Abstract | Links | BibTeX | Altmetric)

2020

Irvine, Katharine M.; Caruso, Melanie; Cestari, Michelle Ferrari; Davis, Gemma M.; Keshvari, Sahar; Sehgal, Anuj; Pridans, Clare; Hume, David A.

Analysis of the impact of CSF‐1 administration in adult rats using a novel textitCsf1r ‐mApple reporter gene (Journal Article)

In: Journal of Leukocyte Biology, vol. 107, no. 2, pp. 221–235, 2020, ISSN: 0741-5400, 1938-3673.

(Links | BibTeX | Altmetric)