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These images were generated as part of the initial detailed characterisation in the early 1980s of the F4/80 antibody as a marker for tissue macrophages using glutaraldehyde-fixed perfusion fixed tissues and paraffin sections (see original references below). This method preserved the ramified processes of tissue macrophages and highlighted several populations that have since been studied in greater detail and the way that they spread along the basement membranes underlying epithelial and endothelial surfaces. The original papers were published in black and white. We now know that F4/80 does not label all macrophages, but these images highlight the abundance, location and morphology of tissue resident macrophages
Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Perry VH, Hume DA, Gordon S.Neuroscience. 1985 Jun;15(2):313-26. doi: 10.1016/0306-4522(85)90215-5.PMID: 3895031
The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia. Hume DA, Perry VH, Gordon S.Anat Rec. 1984 Nov;210(3):503-12. doi: 10.1002/ar.1092100311.PMID: 6524692
The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of endocrine organs. Hume DA, Halpin D, Charlton H, Gordon S.Proc Natl Acad Sci U S A. 1984 Jul;81(13):4174-7. doi: 10.1073/pnas.81.13.4174.PMID: 6377311
The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue. Hume DA, Loutit JF, Gordon S.J Cell Sci. 1984 Mar;66:189-94. doi: 10.1242/jcs.66.1.189.PMID: 6378941
The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. Hume DA, Robinson AP, MacPherson GG, Gordon S.J Exp Med. 1983 Nov 1;158(5):1522-36. doi: 10.1084/jem.158.5.1522.PMID: 6355361
Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. Hume DA, Perry VH, Gordon S.J Cell Biol. 1983 Jul;97(1):253-7. doi: 10.1083/jcb.97.1.253.PMID: 6345555
Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex. Hume DA, Gordon S.J Exp Med. 1983 May 1;157(5):1704-9. doi: 10.1084/jem.157.5.1704.PMID: 6854206