David Hume

Google Scholar Profile

University of Queensland Research Profile

ORCID 0000-0002-2615-1478

Biography

Professor David Hume AO FMedSci FRSE graduated with First Class Honours and a PhD in biochemistry from the Australian National University.  He did his postdoctoral research in the Sir William Dunn School of Pathology in Oxford with Siamon Gordon, where he established his career focus on the biology of macrophages.  This research was recognised with the Bonazinga Award for Excellence from the Society for Leukocyte Biology in 2011.  He was subsequently a Research Fellow at the John Curtin School of Medical Research in Canberra and MD Anderson Cancer Center in Houston before joining  the nascent Centre for Molecular Biology and Biotechnology at the University of Queensland in 1988.  This Centre grew over the next 20 years to become the Institute for Molecular Bioscience (IMB).  At the IMB he was Director of the ARC Centre for Functional and Applied Genomics and Deputy Director of the CRC for Chronic Inflammatory Diseases.  He has published extensively on transcription regulation and transcriptomics and from 2000 to 2015 he was a senior member of the FANTOM Consortium, led by RIKEN in Japan.  In 2006, he was appointed Director of The Roslin Institute at the University of Edinburgh and expanded his interests in both macrophage biology and transcriptomics to multiple species other than humans and experimental animals.  He returned to Australia in 2018 and is currently a Professorial Fellow at Mater Research Institute-University of Queensland where he shares a research group with Dr Kate Irvine.  He currently holds an NHMRC-funded Investigator Grant and grant funding from the Australian Research Council.  His major focus is on the regulation and function of the macrophage colony-stimulating factor receptor (CSF1R) and potential utility of the major ligand (CSF1) in tissue repair and regenerative medicine.

Current and recent research funding

2018-2020         Osteal macrophages as therapeutic targets for fracture repair.  A.Pettit, DA Hume, M Wullschleger, L Raggatt, J. Prins.  NHMRC $638,000

2019-2021         CSF1R and the control of microglial function.  DA Hume, KM Summers NHMRC $467,127

2019-2021         CSF1 therapy for chronic liver disease.  KM Irvine, DA Hume, J. Fawcett, A.Clouston NHMRC $497,127

2021-2023         Macrophage control of mammalian growth and development  Australian Research Council Discovery Grant.  DA Hume, KM Irvine, C. Pridans $564,600

2022-2026         Macrophage Biology in Health and Disease.  NHMRC Leadership L3 Investigator Grant. $3,474,000



Publications:

506 entries « 2 of 11 »

2020

Summers, K. M.; Bush, S. J.; Wu, C.; Su, A. I.; Muriuki, C.; Clark, E. L.; Finlayson, H. A.; Eory, L.; Waddell, L. A.; Talbot, R.; Archibald, A. L.; Hume, D. A.

Functional Annotation of the Transcriptome of the Pig, Sus scrofa, Based Upon Network Analysis of an RNAseq Transcriptional Atlas (Journal Article)

In: Frontiers in Genetics, vol. 10, 2020, ISSN: 16648021, (Publisher: Frontiers Media S.A.).

(Abstract | Links | BibTeX)

Hume, D. A.; Caruso, M.; Ferrari-Cestari, M.; Summers, K. M.; Pridans, C.; Irvine, K. M.

Phenotypic impacts of CSF1R deficiencies in humans and model organisms (Journal Article)

In: Journal of Leukocyte Biology, vol. 107, no. 2, pp. 205–219, 2020, ISSN: 07415400, (Publisher: John Wiley and Sons Inc.).

(Abstract | Links | BibTeX)

Hume, D. A.; Gutowska-Ding, M. W.; Garcia-Morales, C.; Kebede, A.; Bamidele, O.; Trujillo, A. V.; Gheyas, A. A.; Smith, J.

Functional evolution of the colony-stimulating factor 1 receptor (CSF1R) and its ligands in birds (Journal Article)

In: Journal of Leukocyte Biology, vol. 107, no. 2, pp. 237–250, 2020, ISSN: 07415400, (Publisher: John Wiley and Sons Inc.).

(Abstract | Links | BibTeX)

Abbott, C. R.; Hume, D.

The geometry of generalized loxodromic elements (Journal Article)

In: Annales de l’Institut Fourier, vol. 70, no. 4, pp. 1689–1713, 2020, ISSN: 03730956, (Publisher: Association des Annales de l’Institut Fourier).

(Abstract | Links | BibTeX)

Warr, A.; Affara, N.; Aken, B.; Beiki, H.; Bickhart, D. M.; Billis, K.; Chow, W.; Eory, L.; Finlayson, H. A.; Flicek, P.; Girón, C. G.; Griffin, D. K.; Hall, R.; Hannum, G.; Hourlier, T.; Howe, K.; Hume, D. A.; Izuogu, O.; Kim, K.; Koren, S.; Liu, H.; Manchanda, N.; Martin, F. J.; Nonneman, D. J.; O’Connor, R. E.; Phillippy, A. M.; Rohrer, G. A.; Rosen, B. D.; Rund, L. A.; Sargent, C. A.; Schook, L. B.; Schroeder, S. G.; Schwartz, A. S.; Skinner, B. M.; Talbot, R.; Tseng, E.; Tuggle, C. K.; Watson, M.; Smith, T. P. L.; Archibald, A. L.

An improved pig reference genome sequence to enable pig genetics and genomics research (Journal Article)

In: GigaScience, vol. 9, no. 6, 2020, ISSN: 2047217X, (Publisher: Oxford University Press).

(Abstract | Links | BibTeX)

2019

Rojo, R.; Raper, A.; Ozdemir, D. D.; Lefevre, L.; Grabert, K.; Wollscheid-Lengeling, E.; Bradford, B.; Caruso, M.; Gazova, I.; Sánchez, A.; Lisowski, Z. M.; Alves, J.; Molina-Gonzalez, I.; Davtyan, H.; Lodge, R. J.; Glover, J. D.; Wallace, R.; Munro, D. A. D.; David, E.; Amit, I.; Miron, V. E.; Priller, J.; Jenkins, S. J.; Hardingham, G. E.; Blurton-Jones, M.; Mabbott, N. A.; Summers, K. M.; Hohenstein, P.; Hume, D. A.; Pridans, C.

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations (Journal Article)

In: Nature Communications, vol. 10, no. 1, 2019, ISSN: 20411723, (Publisher: Nature Publishing Group).

(Abstract | Links | BibTeX)

Low, W. Y.; Tearle, R.; Bickhart, D. M.; Rosen, B. D.; Kingan, S. B.; Swale, T.; Thibaud-Nissen, F.; Murphy, T. D.; Young, R.; Lefevre, L.; Hume, D. A.; Collins, A.; Ajmone-Marsan, P.; Smith, T. P. L.; Williams, J. L.

Chromosome-level assembly of the water buffalo genome surpasses human and goat genomes in sequence contiguity (Journal Article)

In: Nature Communications, vol. 10, no. 1, 2019, ISSN: 20411723, (Publisher: Nature Publishing Group).

(Abstract | Links | BibTeX)

Freem, L.; Summers, K. M.; Gheyas, A. A.; Psifidi, A.; Boulton, K.; MacCallum, A.; Harne, R.; O’Dell, J.; Bush, S. J.; Hume, D. A.

Analysis of the Progeny of Sibling Matings Reveals Regulatory Variation Impacting the Transcriptome of Immune Cells in Commercial Chickens (Journal Article)

In: Frontiers in Genetics, vol. 10, 2019, ISSN: 16648021, (Publisher: Frontiers Media S.A.).

(Abstract | Links | BibTeX)

Muriuki, C.; Bush, S. J.; Salavati, M.; McCulloch, M. E. B.; Lisowski, Z. M.; Agaba, M.; Djikeng, A.; Hume, D. A.; Clark, E. L.

A Mini-Atlas of Gene Expression for the Domestic Goat (Capra hircus) (Journal Article)

In: Frontiers in Genetics, vol. 10, 2019, ISSN: 16648021, (Publisher: Frontiers Media S.A.).

(Abstract | Links | BibTeX)

Banos, G.; Clark, E. L.; Bush, S. J.; Dutta, P.; Bramis, D. Georgios; Arsenos, G.; Hume, D. A.; Psifidi, A.

Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep (Journal Article)

In: PLoS ONE, vol. 14, no. 11, 2019, ISSN: 19326203, (Publisher: Public Library of Science).

(Abstract | Links | BibTeX)

Stewart, T. A.; Hughes, K.; Hume, D. A.; Davis, F. M.

Developmental Stage-Specific Distribution of Macrophages in Mouse Mammary Gland (Journal Article)

In: Frontiers in Cell and Developmental Biology, vol. 7, 2019, ISSN: 2296634X, (Publisher: Frontiers Media S.A.).

(Abstract | Links | BibTeX)

Salavati, M.; Bush, S. J.; Palma-Vera, S.; McCulloch, M. E. B.; Hume, D. A.; Clark, E. L.

Elimination of Reference Mapping Bias Reveals Robust Immune Related Allele-Specific Expression in Crossbred Sheep (Journal Article)

In: Frontiers in Genetics, vol. 10, 2019, ISSN: 16648021, (Publisher: Frontiers Media S.A.).

(Abstract | Links | BibTeX)

Chundru, V. K.; Marioni, R. E.; Prendergast, J. G. D.; Vallerga, C. L.; Lin, T.; Beveridge, A. J.; Gratten, J.; Hume, D. A.; Deary, I. J.; Wray, N. R.; Visscher, P. M.; McRae, A. F.

Examining the impact of imputation errors on fine-mapping using DNA methylation QTL as a model trait (Journal Article)

In: Genetics, vol. 212, no. 3, pp. 577–586, 2019, ISSN: 00166731, (Publisher: Genetics Society of America).

(Abstract | Links | BibTeX)

Pridans, C.; Raper, A.; Davis, G. M.; Alves, J.; Sauter, K. A.; Lefevre, L.; Regan, T.; Meek, S.; Sutherland, L.; Thomson, A. J.; Clohisey, S.; Bush, S. J.; Rojo, R.; Lisowski, Z. M.; Wallace, R.; Grabert, K.; Upton, K. R.; Tsai, Y. T.; Brown, D.; Smith, L. B.; Summers, K. M.; Mabbott, N. A.; Piccardo, P.; Cheeseman, M. T.; Burdon, T.; Hume, D. A.

Erratum: Pleiotropic impacts of macrophage ands microglial deficiency on development in rats with targeted mutation of the Csf1r locus (Journal of Immunology (2019) 201 (2683-2699) DOI: 10.4049/jimmunol.1701783) (Journal Article)

In: Journal of Immunology, vol. 202, no. 11, pp. 3334–3335, 2019, ISSN: 00221767, (Publisher: American Association of Immunologists).

(Abstract | Links | BibTeX)

Karagianni, A. E.; Summers, K. M.; Couroucé, A.; Depecker, M.; McGorum, B. C.; Hume, D. A.; Pirie, R. S.

The Effect of Race Training on the Basal Gene Expression of Alveolar Macrophages Derived From Standardbred Racehorses (Journal Article)

In: Journal of Equine Veterinary Science, vol. 75, pp. 48–54, 2019, ISSN: 07370806, (Publisher: W.B. Saunders).

(Abstract | Links | BibTeX)

Gow, D. J.; Jackson, H.; Forsythe, P.; Gow, A. G.; Mellanby, R. J.; Hume, D. A.; Nuttall, T.

Measurement of serum macrophage migration inhibitory factor (MIF) and correlation with severity and pruritus scores in client owned dogs with atopic dermatitis (Journal Article)

In: Veterinary Dermatology, vol. 30, no. 2, pp. 115–e32, 2019, ISSN: 09594493, (Publisher: Blackwell Publishing Ltd).

(Abstract | Links | BibTeX)

Prendergast, J. G. D.; Pugh, C.; Harris, S. E.; Hume, D. A.; Deary, I. J.; Beveridge, A.; Zhang, G.

Linked Mutations at Adjacent Nucleotides Have Shaped Human Population Differentiation and Protein Evolution (Journal Article)

In: Genome Biology and Evolution, vol. 11, no. 3, pp. 759–775, 2019, ISSN: 17596653, (Publisher: Oxford University Press).

(Abstract | Links | BibTeX)

Dunning, J.; Blankley, S.; Hoang, L. T.; Cox, M.; Graham, C. M.; James, P. L.; Bloom, C. I.; Chaussabel, D.; Banchereau, J.; Brett, S. J.; Habibi, M. S.; Johnston, S. L.; Hansel, T. T.; Levin, M.; Thwaites, R. S.; Warner, J. O.; Cookson, W. O.; Gazzard, B. G.; Hay, A.; McCauley, J.; Aylin, P.; Ashby, D.; Barclay, W. S.; Elderfield, R. A.; Nadel, S.; Herberg, J. A.; Drumright, L. N.; Garcia-Alvarez, L.; Holmes, A. H.; Kon, O. M.; Aston, S. J.; Gordon, S. B.; Hussell, T.; Thompson, C.; Zambon, M. C.; Baillie, K. J.; Hume, D. A.; Simmonds, P.; Hayward, A.; Smyth, R. L.; McNamara, P. S.; Semple, M. G.; Nguyen-Van-Tam, J. S.; Ho, L. -P.; McMichael, A. J.; Kellam, P.; Adamson, W. E.; Carman, W. F.; Griffiths, M. J.; Moffatt, M. F.; O’Garra, A.; Openshaw, P. J. M.; Investigators, MOSAIC

Correction to: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Nature Immunology, (2018), 19, 6, (625-635), 10.1038/s41590-018-0111-5) (Journal Article)

In: Nature Immunology, vol. 20, no. 3, pp. 373, 2019, ISSN: 15292908, (Publisher: Nature Publishing Group).

(Abstract | Links | BibTeX)

Cordes, M.; Hume, D.

Relatively hyperbolic groups with fixed peripherals (Journal Article)

In: Israel Journal of Mathematics, vol. 230, no. 1, pp. 443–470, 2019, ISSN: 00212172, (Publisher: Springer New York LLC).

(Abstract | Links | BibTeX)

Batoon, L.; Millard, S. M.; Wullschleger, M. E.; Preda, C.; Wu, A. C. -K.; Kaur, S.; Tseng, H. -W.; Hume, D. A.; Levesque, J. -P.; Raggatt, L. J.; Pettit, A. R.

CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair (Journal Article)

In: Biomaterials, vol. 196, pp. 51–66, 2019, ISSN: 01429612, (Publisher: Elsevier Ltd).

(Abstract | Links | BibTeX)

Giotti, B.; Chen, S. -H.; Barnett, M. W.; Regan, T.; Ly, T.; Wiemann, S.; Hume, D. A.; Freeman, T. C.

Assembly of a parts list of the human mitotic cell cycle machinery (Journal Article)

In: Journal of Molecular Cell Biology, vol. 11, no. 8, pp. 703–718, 2019, ISSN: 16742788, (Publisher: Oxford University Press).

(Abstract | Links | BibTeX)

Hu, T.; Wu, Z.; Bush, S. J.; Freem, L.; Vervelde, L.; Summers, K. M.; Hume, D. A.; Balic, A.; Kaiser, P.

Characterization of subpopulations of chicken mononuclear phagocytes that express TIM4 and CSF1R (Journal Article)

In: Journal of Immunology, vol. 202, no. 4, pp. 1186–1199, 2019, ISSN: 00221767, (Publisher: American Association of Immunologists).

(Abstract | Links | BibTeX)

Bush, S. J.; McCulloch, M. E. B.; Muriuki, C.; Salavati, M.; Davis, G. M.; Farquhar, I. L.; Lisowski, Z. M.; Archibald, A. L.; Hume, D. A.; Clark, E. L.

Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression (Journal Article)

In: G3: Genes, Genomes, Genetics, vol. 9, no. 2, pp. 359–373, 2019, ISSN: 21601836, (Publisher: Genetics Society of America).

(Abstract | Links | BibTeX)

Hume, D. A.; Irvine, K. M.; Pridans, C.

The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages (Journal Article)

In: Trends in Immunology, vol. 40, no. 2, pp. 98–112, 2019, ISSN: 14714906, (Publisher: Elsevier Ltd).

(Abstract | Links | BibTeX)

Halachev, M.; Meynert, A.; Taylor, M. S.; Vitart, V.; Kerr, S. M.; Klaric, L.; Consortium, S. G. P.; Aitman, T. J.; Haley, C. S.; Prendergast, J. G.; Pugh, C.; Hume, D. A.; Harris, S. E.; Liewald, D. C.; Deary, I. J.; Semple, C. A.; Wilson, J. F.

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions (Journal Article)

In: PLoS Genetics, vol. 15, no. 11, 2019, ISSN: 15537390, (Publisher: Public Library of Science).

(Abstract | Links | BibTeX)

Balic, A.; Chintoan-Uta, C.; Vohra, P.; Sutton, K. M.; Cassady-Cain, R. L.; Hu, T.; Donaldson, D. S.; Stevens, M. P.; Mabbott, N. A.; Hume, D. A.; Sang, H. M.; Vervelde, L.

Antigen sampling csf1r-expressing epithelial cells are the functional equivalents of mammalian m cells in the avian follicle-associated epithelium (Journal Article)

In: Frontiers in Immunology, vol. 10, no. OCT, 2019, ISSN: 16643224, (Publisher: Frontiers Media S.A.).

(Abstract | Links | BibTeX)

Young, R.; Lefevre, L.; Bush, S. J.; Joshi, A.; Singh, S. H.; Jadhav, S. K.; Lisowski, Z. M.; Iamartino, D.; Summers, K. M.; Williams, J. L.; Archibald, A. L.; Gokhale, S.; Kumar, S.; Hume, D. A.

A gene expression atlas of the domestic water buffalo (Bubalus bubalis) (Journal Article)

In: Frontiers in Genetics, vol. 10, no. JUN, 2019, ISSN: 16648021, (Publisher: Frontiers Media S.A.).

(Links | BibTeX)

Arzhantseva, G. N.; Cashen, C. H.; Gruber, D.; Hume, D.

Negative curvature in graphical small cancellation groups (Journal Article)

In: Groups, Geometry, and Dynamics, vol. 13, no. 2, pp. 579–632, 2019, ISSN: 16617207, (Publisher: European Mathematical Society Publishing House).

(Abstract | Links | BibTeX)

Irvine, K. M.; Ratnasekera, I.; Powell, E. E.; Hume, D. A.

Corrigendum: Causes and consequences of innate immune dysfunction in cirrhosis (Frontiers in Immunology (2019) 10 (293) DOI: 10.3389/fimmu.2019.00293) (Journal Article)

In: Frontiers in Immunology, vol. 10, no. APR, 2019, ISSN: 16643224, (Publisher: Frontiers Media S.A.).

(Abstract | Links | BibTeX)

Irvine, K. M.; Ratnasekera, I.; Powell, E. E.; Hume, D. A.

Casuses and consequences of innate immune dysfucntion in cirrhosis (Journal Article)

In: Frontiers in Immunology, vol. 10, no. FEB, 2019, ISSN: 16643224, (Publisher: Frontiers Media S.A.).

(Abstract | Links | BibTeX)

2018

Sehgal, Anuj; Donaldson, David S.; Pridans, Clare; Sauter, Kristin A.; Hume, David A.; Mabbott, Neil A.

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche (Journal Article)

In: Nature Communications, vol. 9, no. 1, pp. 1272, 2018, ISSN: 2041-1723.

(Links | BibTeX)

Sehgal, Anuj; Donaldson, David S.; Pridans, Clare; Sauter, Kristin A.; Hume, David A.; Mabbott, Neil A.

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche (Journal Article)

In: Nature Communications, vol. 9, no. 1, pp. 1272, 2018, ISSN: 2041-1723.

(Links | BibTeX)

Herron, L. R.; Pridans, C.; Turnbull, M. L.; Smith, N.; Lillico, S.; Sherman, A.; Gilhooley, H. J.; Wear, M.; Kurian, D.; Papadakos, G.; Digard, P.; Hume, D. A.; Gill, A. C.; Sang, H. M.

A chicken bioreactor for efficient production of functional cytokines (Journal Article)

In: BMC Biotechnology, vol. 18, no. 1, 2018, ISSN: 14726750, (Publisher: BioMed Central Ltd.).

(Abstract | Links | BibTeX)

Boulton, K.; Nolan, M. J.; Wu, Z.; Psifidi, A.; Riggio, V.; Harman, K.; Bishop, S. C.; Kaiser, P.; Abrahamsen, M. S.; Hawken, R.; Watson, K. A.; Tomley, F. M.; Blake, D. P.; Hume, D. A.

Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis (Journal Article)

In: Genetics Selection Evolution, vol. 50, no. 1, 2018, ISSN: 0999193X, (Publisher: BioMed Central Ltd.).

(Abstract | Links | BibTeX)

Nirmal, A. J.; Regan, T.; Shih, B. B.; Hume, D. A.; Sims, A. H.; Freeman, T. C.

Immune cell gene signatures for profiling the microenvironment of solid tumors (Journal Article)

In: Cancer Immunology Research, vol. 6, no. 11, pp. 1388–1400, 2018, ISSN: 23266066, (Publisher: American Association for Cancer Research Inc.).

(Abstract | Links | BibTeX)

Pridans, C.; Raper, A.; Davis, G. M.; Alves, J.; Sauter, K. A.; Lefevre, L.; Regan, T.; Meek, S.; Sutherland, L.; Thomson, A. J.; Clohisey, S.; Bush, S. J.; Rojo, R.; Lisowski, Z. M.; Wallace, R.; Grabert, K.; Upton, K. R.; Tsai, Y. T.; Brown, D.; Smith, L. B.; Summers, K. M.; Mabbott, N. A.; Piccardo, P.; Cheeseman, M. T.; Burdon, T.; Hume, D. A.

Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus (Journal Article)

In: Journal of Immunology, vol. 201, no. 9, pp. 2683–2699, 2018, ISSN: 00221767, (Publisher: American Association of Immunologists).

(Abstract | Links | BibTeX)

Waddell, L. A.; Lefevre, L.; Bush, S. J.; Raper, A.; Young, R.; Lisowski, Z. M.; McCulloch, M. E. B.; Muriuki, C.; Sauter, K. A.; Clark, E. L.; Irvine, K. M.; Pridans, C.; Hope, J. C.; Hume, D. A.

ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages (Journal Article)

In: Frontiers in Immunology, vol. 9, no. OCT, 2018, ISSN: 16643224, (Publisher: Frontiers Media S.A.).

(Abstract | Links | BibTeX)

Brown, S. M.; Bush, S. J.; Summers, K. M.; Hume, D. A.; Lawrence, A. B.

Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity (Journal Article)

In: Behavioural Brain Research, vol. 350, pp. 6–15, 2018, ISSN: 01664328, (Publisher: Elsevier B.V.).

(Abstract | Links | BibTeX)

Scott, C. L.; T’Jonck, W.; Martens, L.; Todorov, H.; Sichien, D.; Soen, B.; Bonnardel, J.; Prijck, S. De; Vandamme, N.; Cannoodt, R.; Saelens, W.; Vanneste, B.; Toussaint, W.; Bleser, P. De; Takahashi, N.; Vandenabeele, P.; Henri, S.; Pridans, C.; Hume, D. A.; Lambrecht, B. N.; Baetselier, P. De; Milling, S. W. F.; Ginderachter, J. A. Van; Malissen, B.; Berx, G.; Beschin, A.; Saeys, Y.; Guilliams, M.

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages (Journal Article)

In: Immunity, vol. 49, no. 2, pp. 312–325.e5, 2018, ISSN: 10747613, (Publisher: Cell Press).

(Abstract | Links | BibTeX)

Kaur, S.; Raggatt, L. J.; Millard, S. M.; Wu, A. C.; Batoon, L.; Jacobsen, R. N.; Winkler, I. G.; MacDonald, K. P.; Perkins, A. C.; Hume, D. A.; Levesque, J. -P.; Pettit, A. R.

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment (Journal Article)

In: Blood, vol. 132, no. 7, pp. 735–749, 2018, ISSN: 00064971, (Publisher: American Society of Hematology).

(Abstract | Links | BibTeX)

Bush, S. J.; Freem, L.; MacCallum, A. J.; O’Dell, J.; Wu, C.; Afrasiabi, C.; Psifidi, A.; Stevens, M. P.; Smith, J.; Summers, K. M.; Hume, D. A.

Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken (Journal Article)

In: BMC Genomics, vol. 19, no. 1, 2018, ISSN: 14712164, (Publisher: BioMed Central Ltd.).

(Abstract | Links | BibTeX)

Jubb, A. W.; Hofer, T. P.; Hume, D. A.; Ziegler-Heitbrock, L.

The preterm labor associated ADAMTS2 gene is induced by glucocorticoids (Journal Article)

In: American Journal of Obstetrics and Gynecology, vol. 219, no. 1, pp. 122–123, 2018, ISSN: 00029378, (Publisher: Mosby Inc.).

(Links | BibTeX)

Pandit, R. J.; Hinsu, A. T.; Patel, N. V.; Koringa, P. G.; Jakhesara, S. J.; Thakkar, J. R.; Shah, T. M.; Limon, G.; Psifidi, A.; Guitian, J.; Hume, D. A.; Tomley, F. M.; Rank, D. N.; Raman, M.; Tirumurugaan, K. G.; Blake, D. P.; Joshi, C. G.

Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing (Journal Article)

In: Microbiome, vol. 6, no. 1, 2018, ISSN: 20492618, (Publisher: BioMed Central Ltd.).

(Abstract | Links | BibTeX)

Dunning, J.; Blankley, S.; Hoang, L. T.; Cox, M.; Graham, C. M.; James, P. L.; Bloom, C. I.; Chaussabel, D.; Banchereau, J.; Brett, S. J.; Habibi, M. S.; Johnston, S. L.; Hansel, T. T.; Levin, M.; Thwaites, R. S.; Warner, J. O.; Cookson, W. O.; Gazzard, B. G.; Hay, A.; McCauley, J.; Aylin, P.; Ashby, D.; Barclay, W. S.; Elderfield, R. A.; Nadel, S.; Herberg, J. A.; Drumright, L. N.; Garcia-Alvarez, L.; Holmes, A. H.; Kon, O. M.; Aston, S. J.; Gordon, S. B.; Hussell, T.; Thompson, C.; Zambon, M. C.; Baillie, K. J.; Hume, D. A.; Simmonds, P.; Hayward, A.; Smyth, R. L.; McNamara, P. S.; Semple, M. G.; Nguyen-Van-Tam, J. S.; Ho, L. -P.; McMichael, A. J.; Kellam, P.; Adamson, W. E.; Carman, W. F.; Griffiths, M. J.; Moffatt, M. F.; O’Garra, A.; Openshaw, P. J. M.

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (Journal Article)

In: Nature Immunology, vol. 19, no. 6, pp. 625–635, 2018, ISSN: 15292908, (Publisher: Nature Publishing Group).

(Abstract | Links | BibTeX)

Lisowski, Z. M.; Pirie, R. S.; Blikslager, A. T.; Lefebvre, D.; Hume, D. A.; Hudson, N. P. H.

An update on equine post-operative ileus: Definitions, pathophysiology and management (Journal Article)

In: Equine Veterinary Journal, vol. 50, no. 3, pp. 292–303, 2018, ISSN: 04251644, (Publisher: Equine Veterinary Journal Ltd).

(Abstract | Links | BibTeX)

Bush, S. J.; Muriuki, C.; McCulloch, M. E. B.; Farquhar, I. L.; Clark, E. L.; Hume, D. A.

Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome (Journal Article)

In: Genetics Selection Evolution, vol. 50, no. 1, 2018, ISSN: 0999193X, (Publisher: BioMed Central Ltd.).

(Abstract | Links | BibTeX)

Regan, T.; Gill, A. C.; Clohisey, S. M.; Barnett, M. W.; Pariante, C. M.; Harrison, N. A.; Hume, D. A.; Bullmore, E. T.; Freeman, T. C.; Consortium, MRC Immunopsychiatry

Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages (Journal Article)

In: Journal of Leukocyte Biology, vol. 103, no. 4, pp. 681–692, 2018, ISSN: 07415400, (Publisher: John Wiley and Sons Inc.).

(Abstract | Links | BibTeX)

Hawley, C. A.; Rojo, R.; Raper, A.; Sauter, K. A.; Lisowski, Z. M.; Grabert, K.; Bain, C. C.; Davis, G. M.; Louwe, P. A.; Ostrowski, M. C.; Hume, D. A.; Pridans, C.; Jenkins, S. J.

Csf1r-mApple transgene expression and ligand binding in vivo reveal dynamics of CSF1R expression within the mononuclear phagocyte system (Journal Article)

In: Journal of Immunology, vol. 200, no. 6, pp. 2209–2223, 2018, ISSN: 00221767, (Publisher: American Association of Immunologists).

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Baillie, J. K.; Bretherick, A.; Haley, C. S.; Clohisey, S.; Gray, A.; Neyton, L. P. A.; Barrett, J.; Stahl, E. A.; Tenesa, A.; Andersson, R.; Brown, J. B.; Faulkner, G. J.; Lizio, M.; Schaefer, U.; Daub, C.; Itoh, M.; Kondo, N.; Lassmann, T.; Kawai, J.; Mole, D.; Bajic, V. B.; Heutink, P.; Rehli, M.; Kawaji, H.; Sandelin, A.; Suzuki, H.; Satsangi, J.; Wells, C. A.; Hacohen, N.; Freeman, T. C.; Hayashizaki, Y.; Carninci, P.; Forrest, A. R. R.; Hume, D. A.; Consortium, IIBDGC

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease (Journal Article)

In: PLoS Computational Biology, vol. 14, no. 3, 2018, ISSN: 1553734X, (Publisher: Public Library of Science).

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Pridans, C.; Sauter, K. A.; Irvine, K. M.; Davis, G. M.; Lefevre, L.; Raper, A.; Rojo, R.; Nirmal, A. J.; Beard, P.; Cheeseman, M.; Hume, D. A.

Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats (Journal Article)

In: American Journal of Physiology – Gastrointestinal and Liver Physiology, vol. 314, no. 3, pp. G388–G398, 2018, ISSN: 01931857, (Publisher: American Physiological Society).

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