David Hume

Google Scholar Profile

University of Queensland Research Profile

ORCID 0000-0002-2615-1478

Biography

Professor David Hume AO FMedSci FRSE graduated with First Class Honours and a PhD in biochemistry from the Australian National University.  He did his postdoctoral research in the Sir William Dunn School of Pathology in Oxford with Siamon Gordon, where he established his career focus on the biology of macrophages.  This research was recognised with the Bonazinga Award for Excellence from the Society for Leukocyte Biology in 2011.  He was subsequently a Research Fellow at the John Curtin School of Medical Research in Canberra and MD Anderson Cancer Center in Houston before joining  the nascent Centre for Molecular Biology and Biotechnology at the University of Queensland in 1988.  This Centre grew over the next 20 years to become the Institute for Molecular Bioscience (IMB).  At the IMB he was Director of the ARC Centre for Functional and Applied Genomics and Deputy Director of the CRC for Chronic Inflammatory Diseases.  He has published extensively on transcription regulation and transcriptomics and from 2000 to 2015 he was a senior member of the FANTOM Consortium, led by RIKEN in Japan.  In 2006, he was appointed Director of The Roslin Institute at the University of Edinburgh and expanded his interests in both macrophage biology and transcriptomics to multiple species other than humans and experimental animals.  He returned to Australia in 2018 and is currently a Professorial Fellow at Mater Research Institute-University of Queensland where he shares a research group with Dr Kate Irvine.  He currently holds an NHMRC-funded Investigator Grant and grant funding from the Australian Research Council.  His major focus is on the regulation and function of the macrophage colony-stimulating factor receptor (CSF1R) and potential utility of the major ligand (CSF1) in tissue repair and regenerative medicine.

Current and recent research funding

2018-2020         Osteal macrophages as therapeutic targets for fracture repair.  A.Pettit, DA Hume, M Wullschleger, L Raggatt, J. Prins.  NHMRC $638,000

2019-2021         CSF1R and the control of microglial function.  DA Hume, KM Summers NHMRC $467,127

2019-2021         CSF1 therapy for chronic liver disease.  KM Irvine, DA Hume, J. Fawcett, A.Clouston NHMRC $497,127

2021-2023         Macrophage control of mammalian growth and development  Australian Research Council Discovery Grant.  DA Hume, KM Irvine, C. Pridans $564,600

2022-2026         Macrophage Biology in Health and Disease.  NHMRC Leadership L3 Investigator Grant. $3,474,000



Publications:

506 entries « 10 of 11 »

1992

Hume, D. A.; Denkins, Y.

The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice (Journal Article)

In: Lymphokine and Cytokine Research, vol. 11, no. 2, pp. 95–98, 1992, ISSN: 10565477.

(Abstract | Links | BibTeX)

Lüthe, R.; Hume, D.

Rezensionen (Journal Article)

In: Deutsche Zeitschrift fur Philosophie, vol. 40, no. 12, pp. 1471–1488, 1992, ISSN: 00121045.

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Hume, D.; McGarry, M. P.; Stewart, C.

Letter to the editor [1] (Journal Article)

In: Journal of Leukocyte Biology, vol. 51, no. 5, pp. 517–518, 1992, ISSN: 07415400.

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1991

Cassady, A. I.; Stacey, K. J.; Nimmo, K. A.; Murphy, K. M.; Ahe, D. Von Der; Pearson, D.; Botteri, F. M.; Nagamine, Y.; Hume, D. A.

Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5′ non-coding sequences that are conserved between mouse and pig (Journal Article)

In: Nucleic Acids Research, vol. 19, no. 24, pp. 6839–6847, 1991, ISSN: 03051048.

(Abstract | Links | BibTeX)

Breen, F. N.; Hume, D. A.; Weidemann, M. J.

Interactions among granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IFN-γ lead to enhanced proliferation of murine macrophage progenitor cells (Journal Article)

In: Journal of Immunology, vol. 147, no. 5, pp. 1542–1547, 1991, ISSN: 00221767.

(Abstract | Links | BibTeX)

Le, F.; Wilce, P. A.; Cassady, I.; Hume, D. A.; Shanley, B. C.

Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain. (Journal Article)

In: Alcohol and alcoholism (Oxford, Oxfordshire). Supplement., vol. 1, pp. 211–214, 1991, ISSN: 13586173.

(Abstract | Links | BibTeX)

Abd, A. -H. A.; Savage, N. W.; Halliday, W. J.; Hume, D. A.

The role of macrophages in experimental arthritis induced by Streptococcus agalactiae sonicate: Actions of macrophage colony-stimulating factor (CSF-1) and other macrophage-modulating agents (Journal Article)

In: Lymphokine and Cytokine Research, vol. 10, no. 1-2, pp. 43–50, 1991, ISSN: 02776766.

(Abstract | Links | BibTeX)

1990

Pavli, P.; Woodhams, C. E.; Doe, W. F.; Hume, D. A.

Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria (Journal Article)

In: Immunology, vol. 70, no. 1, pp. 40–47, 1990, ISSN: 00192805.

(Abstract | Links | BibTeX)

Breen, F. N.; Hume, D. A.; Weidemann, M. J.

The effects of interleukin 3 (IL‐3) on cells responsive to macrophage colony‐stimulating factor (CSF‐1) in liquid murine bone marrow culture (Journal Article)

In: British Journal of Haematology, vol. 74, no. 2, pp. 138–145, 1990, ISSN: 00071048.

(Abstract | Links | BibTeX)

Abd, A. -H. A.; Hume, D. A.; Halliday, W. J.; Davis, G. H. G.

Immunopathological investigations during the course of arthritis induced in rats by Streptococcus agalactiae (Journal Article)

In: Medical Microbiology and Immunology, vol. 179, no. 1, pp. 13–23, 1990, ISSN: 03008584.

(Abstract | Links | BibTeX)

Hume, D.

Macrophage colony-stimulating factor (Journal Article)

In: Today’s Life Science, vol. 2, no. 6, pp. 20–22+28, 1990, ISSN: 10336893.

(Links | BibTeX)

1989

Hume, D. A.; Nayar, R.

Encapsulation is not involved in the activities of recombinant gamma interferon associated with multilamellar phospholipid liposomes on murine bone marrow-derived macrophages (Journal Article)

In: Lymphokine Research, vol. 8, no. 4, pp. 415–425, 1989, ISSN: 02776766.

(Abstract | Links | BibTeX)

Hume, D. A.; Denkins, Y. M.

Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction (Journal Article)

In: Immunology and Cell Biology, vol. 67, no. 4, pp. 243–249, 1989, ISSN: 08189641.

(Abstract | Links | BibTeX)

1988

Schackert, G.; Simmons, R. D.; Buzbee, T. M.; Hume, D. A.; Fidler, I. J.

Macrophage infiltration into experimental brain metastases: Occurrence through an intact blood-brain barrier (Journal Article)

In: Journal of the National Cancer Institute, vol. 80, no. 13, pp. 1027–1034, 1988, ISSN: 00278874.

(Abstract | Links | BibTeX)

Russell, P. J.; Philips, J.; Allan, W.; Hume, D. A.

Antigenic variation and macrophage infiltration of human bladder tumors xenografted into nude mice (Journal Article)

In: Journal of Leukocyte Biology, vol. 43, no. 4, pp. 335–342, 1988, ISSN: 07415400.

(Abstract | Links | BibTeX)

Simeonovic, C. J.; Hodder, M. J.; Hume, D. A.

Role of Ia-positive leukocytes and F4/80-positive macrophages in the immunogenicity of fetal mouse proislets and fetal pancreas (Journal Article)

In: Transplantation Proceedings, vol. 20, no. 1, pp. 68–71, 1988, ISSN: 00411345.

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Hume, D. A.; Pavli, P.; Donahue, R. E.; Fidler, I. J.

The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo (Journal Article)

In: Journal of Immunology, vol. 141, no. 10, pp. 3405–3409, 1988, ISSN: 00221767.

(Abstract | Links | BibTeX)

McLachlan, J. C.; Macintyre, J.; Hume, D. D.; Smith, J.

Direct demonstration of production of transforming growth factor activity by embryonic chick tissue (Journal Article)

In: Experientia, vol. 44, no. 4, pp. 351–352, 1988, ISSN: 00144754, (Publisher: Birkhäuser-Verlag).

(Abstract | Links | BibTeX)

1987

Hume, D. A.

Growth regulation in murine bone marrow-derived macrophages: Effects of contaminating endotoxin in commercial GM CSF and interleukin 4 (Journal Article)

In: Lymphokine Research, vol. 6, no. 4, pp. 357–359, 1987, ISSN: 02776766.

(Abstract | Links | BibTeX)

Hume, D. A.; Allan, W.; Fabrus, B.; Weidemann, M. J.; Hapel, A. J.; Bartelmez, S.

Regulation of proliferation of bone marrow-derived macrophages (Journal Article)

In: Lymphokine Research, vol. 6, no. 2, pp. 127–139, 1987, ISSN: 02776766.

(Abstract | Links | BibTeX)

Hume, D. A.; Allan, W.; Hogan, P. G.; Doe, W. F.

Immunohistochemical characterisation of macrophages in human liver and gastrointestinal tract: Expression of CD4, HLA-DR, OKM1, and the mature macrophage marker 25F9 in normal and diseased tissue (Journal Article)

In: Journal of Leukocyte Biology, vol. 42, no. 5, pp. 474–484, 1987, ISSN: 07415400.

(Abstract | Links | BibTeX)

Warren, H. S.; Simeonovic, C. J.; Allan, W.; Hume, D. A.

Induced expression of class II major histocompatibility complex antigens on thyroid but not pancreatic islet allografts following transfer of sensitized LYT2+ Ŧ cells (Journal Article)

In: Transplantation Proceedings, vol. 19, no. 1 I, pp. 213, 1987, ISSN: 00411345.

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Müllbacher, A.; Hume, D.; Braithwaite, A. W.; Waring, P.; Eichner, R. D.

Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin (Journal Article)

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 84, no. 11, pp. 3822–3825, 1987, ISSN: 00278424.

(Abstract | Links | BibTeX)

1986

Dixon, J. E.; Allan, J. E.; Doherty, P. C.; Hume, D. A.

Immunohistochemical analysis of the involvement of F4/80 and Ia-positive macrophages in mouse liver infected with lymphocytic choriomeningitis virus (Journal Article)

In: Journal of Leukocyte Biology, vol. 40, no. 5, pp. 617–628, 1986, ISSN: 07415400.

(Abstract | Links | BibTeX)

Gordon, S.; Crocker, P. R.; Morris, L.; Lee, S. H.; Perry, V. H.; Hume, D. A.

Localization and function of tissue macrophages. (Journal Article)

In: Ciba Foundation symposium, vol. 118, pp. 54–67, 1986, ISSN: 03005208.

(Abstract | Links | BibTeX)

1985

Hume, D. A.

The biology of macrophages. (Journal Article)

In: Science progress, vol. 69, no. 276, pp. 485–494, 1985, ISSN: 00368504.

(Links | BibTeX)

Hapel, A. J.; Osborne, J. M.; Fung, O. M.; Young, I. G.; Allan, W.; Hume, D. A.

Expression of 20-α-hydroxysteroid dehydrogenase in mouse macrophages, hemopoietic cells, and cell lines and its induction by colony-stimulating factors (Journal Article)

In: Journal of Immunology, vol. 134, no. 4, pp. 2492–2497, 1985, ISSN: 00221767.

(Abstract | Links | BibTeX)

Hume, D. A.; Summers, K. M.; Cohen, D. R.; Allan, W.

Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines (Journal Article)

In: FEBS Letters, vol. 180, no. 2, pp. 271–274, 1985, ISSN: 00145793.

(Abstract | Links | BibTeX)

Perry, V. H.; Hume, D. A.; Gordon, S.

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain (Journal Article)

In: Neuroscience, vol. 15, no. 2, pp. 313–326, 1985, ISSN: 03064522.

(Abstract | Links | BibTeX)

Hume, D. A.

Immunohistochemical Analysis of Murine Mononuclear Phagocytes that Express Class II Major Histocompatibility Antigens (Journal Article)

In: Immunobiology, vol. 170, no. 5, pp. 381–389, 1985, ISSN: 01712985.

(Abstract | Links | BibTeX)

Hume, D. A.; Allan, W.; Golder, J.; Stephens, R. W.; Doe, W. F.; Warren, H. S.

Preparation and characterization of human bone marrow-derived macrophages (Journal Article)

In: Journal of Leukocyte Biology, vol. 38, no. 4, pp. 541–552, 1985, ISSN: 07415400.

(Abstract | Links | BibTeX)

Stephens, R. W.; Golder, J. P.; Fayle, D. R. H.; Hume, D. A.; Hapel, A. J.; Allan, W.; Fordham, C. J.; Doe, W. F.

Minactivin expression in human monocyte and macrophage populations (Journal Article)

In: Blood, vol. 66, no. 2, pp. 333–337, 1985, ISSN: 00064971.

(Abstract | Links | BibTeX)

Summers, K. M.; Hume, D. A.

Expression of glandular kallikrein genes in lymphoid and hemopoietic tissues and cell lines (Journal Article)

In: Lymphokine Research, vol. 4, no. 3, pp. 229–235, 1985, ISSN: 02776766.

(Links | BibTeX)

Russell, P. J.; Cahill, J.; Cameron, F.; Hume, D.

Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice (Journal Article)

In: Journal of Leukocyte Biology, vol. 38, no. 2, pp. 241–254, 1985, ISSN: 07415400.

(Abstract | Links | BibTeX)

1984

Hume, D. A.; Perry, V. H.; Gordon, S.

The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: Macrophages associated with epithelia (Journal Article)

In: The Anatomical Record, vol. 210, no. 3, pp. 503–512, 1984, ISSN: 0003276X.

(Abstract | Links | BibTeX)

Hume, D. A.; Gordon, S.

The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages. Opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E (Journal Article)

In: Experimental Cell Research, vol. 150, no. 2, pp. 347–355, 1984, ISSN: 00144827.

(Abstract | Links | BibTeX)

Hume, D. A.; Loutit, J. F.; Gordon, S.

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Macrophages of bone and associated connective tissue (Journal Article)

In: Journal of Cell Science, vol. VOL. 66, pp. 189–194, 1984, ISSN: 00219533.

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Hapel, A. J.; Warren, H. S.; Hume, D. A.

Different colony-stimulating factors are detected by the ‘interleukin-3’-dependent cell lines FDC-Pl and 32D cl-23 (Journal Article)

In: Blood, vol. 64, no. 4, pp. 786–790, 1984, ISSN: 00064971.

(Abstract | Links | BibTeX)

Hume, D. A.; Halpin, D.; Charlton, H.; Gordon, S.

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Macrophages of endocrine organs (Journal Article)

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 81, no. 13 I, pp. 4174–4177, 1984, ISSN: 00278424.

(Abstract | Links | BibTeX)

1983

Hume, D. A.; Robinson, A. P.; Macpherson, G. G.; Gordon, S.

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Relationship between macrophages, langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs (Journal Article)

In: Journal of Experimental Medicine, vol. 158, no. 5, pp. 1522–1536, 1983, ISSN: 00221007.

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Hume, D. A.; Gordon, S.; Thornalley, P. J.; Bannister, J. V.

The production of oxygen-centered radicals by Bacillus-Calmette-Guerin-activated macrophages. An electron paramagnetic resonance study of the response to phorbol myristate acetate (Journal Article)

In: BBA – Molecular Cell Research, vol. 763, no. 3, pp. 245–250, 1983, ISSN: 01674889.

(Abstract | Links | BibTeX)

Hume, D. A.; Gordon, S.

Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex (Journal Article)

In: Journal of Experimental Medicine, vol. 157, no. 5, pp. 1704–1709, 1983, ISSN: 00221007.

(Links | BibTeX)

Hume, D. A.; Gordon, S.

Optimal conditions for proliferation of bone marrow‐derived mouse macrophages in culture: The roles of CSF‐1, serum, Ca2+, and adherence (Journal Article)

In: Journal of Cellular Physiology, vol. 117, no. 2, pp. 189–194, 1983, ISSN: 00219541.

(Abstract | Links | BibTeX)

Hume, D. A.; Perry, V. H.; Gordon, S.

Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: Phagocytosis of dying neurons and differentiation in microglial cells to form a regular array in the plexiform layers (Journal Article)

In: Journal of Cell Biology, vol. 97, no. 1, pp. 253–257, 1983, ISSN: 00219525.

(Abstract | Links | BibTeX)

1982

Hume, D. A.; Gordon, S.

Regulation of bone-marrow macrophage proliferation. (Journal Article)

In: Advances in experimental medicine and biology, vol. 155, pp. 261–266, 1982, ISSN: 00652598.

(Links | BibTeX)

1981

Hume, D. A.; Wrogemann, K.; Ferber, E.; Kolbuch-Braddon, M. E.; Taylor, R. M.; Fischer, H.; Weidemann, M. J.

Concanavalin A-induced chemiluminescence in rat thymus lymphocytes. Its origin and role in mitogenesis (Journal Article)

In: Biochemical Journal, vol. 198, no. 3, pp. 661–667, 1981, ISSN: 02646021.

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1979

Hume, D. A.; Weidemann, M. J.; Ferber, E.

Preferential inhibition by quercetin of mitogen-stimulated thymocyte glucose transport (Journal Article)

In: Journal of the National Cancer Institute, vol. 62, no. 5, pp. 1243–1249, 1979, ISSN: 00278874.

(Abstract | Links | BibTeX)

Hume, D. A.; Thornton, M. R.; Weidemann, M. J.; Speth, V.

Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli (Journal Article)

In: Journal of Cellular Physiology, vol. 101, no. 3, pp. 523–528, 1979, ISSN: 00219541.

(Abstract | Links | BibTeX)

Hume, D. A.; Weidemann, M. J.

Role and regulation of glucose metabolism in proliferating cells (Journal Article)

In: Journal of the National Cancer Institute, vol. 62, no. 1, pp. 3–8, 1979, ISSN: 00278874.

(Abstract | Links | BibTeX)

1978

Hume, D. A.; Hansen, K.; Weidemann, M. J.; Ferber, E.

Cytochalasin B inhibits lymphocyte transformation through its effects on glucose transport (Journal Article)

In: Nature, vol. 272, no. 5651, pp. 359, 1978, ISSN: 00280836.

(Abstract | Links | BibTeX)

506 entries « 10 of 11 »