Anuj Sehgal

Biography

Anuj completed his PhD at the Roslin Institute in 2017 after which he joined the Institute of Infection, Immunity & Inflammation working on an Industry funded preclinical trial of novel checkpoint inhibitors in autoimmune disease models. He then moved to Brisbane in late 2018 to work in the Bones and Immunology Laboratory (Prof. Allison Pettit) at Mater Research Institute – University of Queensland (MRI-UQ) before making an internal transfer to the Macrophage Biology group in Jan 2021. He is also an Epithelial Cell Biology Lecturer at the School of Biomedical Science (UQ).

Anuj’s long term research mission is to determine how macrophages function and shape the functions of their immediate local environment. For example, how do macrophages interact with the epithelial lining of the small intestine to control epithelial regeneration, absorption through epithelial cells, paracellular permeability and response to invasion through the epithelial barrier.

AnujSehgal


Publications:

2022

Stables, Jennifer; Green, Emma K; Sehgal, Anuj; Patkar, Omkar L; Keshvari, Sahar; Taylor, Isis; Ashcroft, Maisie E; Grabert, Kathleen; Wollscheid-Lengeling, Evi; Szymkowiak, Stefan; McColl, Barry W; Adamson, Antony; Humphreys, Neil E; Mueller, Werner; Starobova, Hana; Vetter, Irina; Shabestari, Sepideh Kiani; Blurton-Jones, Matthew M; Summers, Kim M; Irvine, Katharine M; Pridans, Clare; Hume, David A

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling (Journal Article)

In: Development, vol. 149, no. 8, 2022, ISSN: 1477-9129.

(Abstract | Links | BibTeX | Altmetric)

2021

Kaur, Simranpreet; Sehgal, Anuj; Wu, Andy C.; Millard, Susan M.; Batoon, Lena; Sandrock, Cheyenne J.; Ferrari-Cestari, Michelle; Levesque, Jean-Pierre; Hume, David A.; Raggatt, Liza J.; Pettit, Allison R.

Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice (Journal Article)

In: Journal of Hematology & Oncology, vol. 14, no. 1, pp. 3, 2021, ISSN: 1756-8722.

(Abstract | Links | BibTeX | Altmetric)

Keshvari, Sahar; Caruso, Melanie; Teakle, Ngari; Batoon, Lena; Sehgal, Anuj; Patkar, Omkar L.; Ferrari-Cestari, Michelle; Snell, Cameron E.; Chen, Chen; Stevenson, Alex; Davis, Felicity M.; Bush, Stephen J.; Pridans, Clare; Summers, Kim M.; Pettit, Allison R.; Irvine, Katharine M.; Hume, David A.

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation (Journal Article)

In: PLOS Genetics, vol. 17, no. 6, pp. e1009605, 2021, ISSN: 1553-7404.

(Abstract | Links | BibTeX | Altmetric)

Hume, David A.; Caruso, Melanie; Keshvari, Sahar; Patkar, Omkar L.; Sehgal, Anuj; Bush, Stephen J.; Summers, Kim M.; Pridans, Clare; Irvine, Katharine M.

The Mononuclear Phagocyte System of the Rat (Journal Article)

In: The Journal of Immunology, vol. 206, no. 10, pp. 2251–2263, 2021, ISSN: 0022-1767, 1550-6606.

(Links | BibTeX | Altmetric)

Sehgal, Anuj; Irvine, Katharine M; Hume, David A

Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair (Journal Article)

In: Semin Immunol, vol. 54, pp. 101509, 2021, ISSN: 1096-3618.

(Abstract | Links | BibTeX | Altmetric)

Kaur, Simranpreet; Sehgal, Anuj; Wu, Andy C; Millard, Susan M; Batoon, Lena; Sandrock, Cheyenne J; Ferrari-Cestari, Michelle; Levesque, Jean-Pierre; Hume, David A; Raggatt, Liza J; Pettit, Allison R

Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice (Journal Article)

In: Journal of Hematology & Oncology, vol. 14, no. 1, pp. 3, 2021, ISSN: 1756-8722.

(Abstract | Links | BibTeX | Altmetric)

Keshvari, Sahar; Caruso, Melanie; Teakle, Ngari; Batoon, Lena; Sehgal, Anuj; Patkar, Omkar L; Ferrari-Cestari, Michelle; Snell, Cameron E; Chen, Chen; Stevenson, Alex; Davis, Felicity M; Bush, Stephen J; Pridans, Clare; Summers, Kim M; Pettit, Allison R; Irvine, Katharine M; Hume, David A

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation (Journal Article)

In: PLOS Genetics, vol. 17, no. 6, pp. e1009605, 2021, ISSN: 1553-7404, (Publisher: Public Library of Science).

(Abstract | Links | BibTeX | Altmetric)

Millard, Susan M; Heng, Ostyn; Opperman, Khatora S; Sehgal, Anuj; Irvine, Katharine M; Kaur, Simranpreet; Sandrock, Cheyenne J; Wu, Andy C; Magor, Graham W; Batoon, Lena; Perkins, Andrew C; Noll, Jacqueline E; Zannettino, Andrew C W; Sester, David P; Levesque, Jean-Pierre; Hume, David A; Raggatt, Liza J; Summers, Kim M; Pettit, Allison R

Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues (Journal Article)

In: Cell Rep, vol. 37, no. 8, pp. 110058, 2021, ISSN: 2211-1247.

(Abstract | Links | BibTeX | Altmetric)

2020

Grabert, Kathleen; Sehgal, Anuj; Irvine, Katharine M.; Wollscheid-Lengeling, Evi; Ozdemir, Derya D.; Stables, Jennifer; Luke, Garry A.; Ryan, Martin D.; Adamson, Antony; Humphreys, Neil E.; Sandrock, Cheyenne J.; Rojo, Rocio; Verkasalo, Veera A.; Mueller, Werner; Hohenstein, Peter; Pettit, Allison R.; Pridans, Clare; Hume, David A.

A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System (Journal Article)

In: The Journal of Immunology, vol. 205, no. 11, pp. 3154–3166, 2020, ISSN: 0022-1767, 1550-6606.

(Links | BibTeX | Altmetric)

Irvine, Katharine M.; Caruso, Melanie; Cestari, Michelle Ferrari; Davis, Gemma M.; Keshvari, Sahar; Sehgal, Anuj; Pridans, Clare; Hume, David A.

Analysis of the impact of CSF‐1 administration in adult rats using a novel textitCsf1r ‐mApple reporter gene (Journal Article)

In: Journal of Leukocyte Biology, vol. 107, no. 2, pp. 221–235, 2020, ISSN: 0741-5400, 1938-3673.

(Links | BibTeX | Altmetric)

2018

Sehgal, Anuj; Donaldson, David S.; Pridans, Clare; Sauter, Kristin A.; Hume, David A.; Mabbott, Neil A.

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche (Journal Article)

In: Nature Communications, vol. 9, no. 1, pp. 1272, 2018, ISSN: 2041-1723.

(Links | BibTeX | Altmetric)

Hamilton, Carly A.; Young, Rachel; Jayaraman, Siddharth; Sehgal, Anuj; Paxton, Edith; Thomson, Sarah; Katzer, Frank; Hope, Jayne; Innes, Elisabeth; Morrison, Liam J.; Mabbott, Neil A.

Development of in vitro enteroids derived from bovine small intestinal crypts (Journal Article)

In: Veterinary Research, vol. 49, no. 1, pp. 54, 2018, ISSN: 1297-9716.

(Links | BibTeX | Altmetric)

Sehgal, Anuj; Donaldson, David S.; Pridans, Clare; Sauter, Kristin A.; Hume, David A.; Mabbott, Neil A.

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche (Journal Article)

In: Nature Communications, vol. 9, no. 1, pp. 1272, 2018, ISSN: 2041-1723.

(Links | BibTeX | Altmetric)

2017

Sehgal, Anuj; Kobayashi, Atsushi; Donaldson, David S.; Mabbott, Neil A.

c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium (Journal Article)

In: Immunobiology, vol. 222, no. 2, pp. 316–326, 2017, ISSN: 01712985.

(Links | BibTeX | Altmetric)

2016

Donaldson, David S.; Sehgal, Anuj; Rios, Daniel; Williams, Ifor R.; Mabbott, Neil A.

Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility (Journal Article)

In: PLOS Pathogens, vol. 12, no. 12, pp. e1006075, 2016, ISSN: 1553-7374.

(Links | BibTeX | Altmetric)

2015

Mabbott, Neil A; Sehgal, Anuj; Donaldson, David S

M Cells (Incollection)

In: Ltd, John Wiley Sons (Ed.): eLS, pp. 1–9, John Wiley & Sons, Ltd, Chichester, UK, 2015, ISBN: 978-0-470-01590-2 978-0-470-01617-6.

(Links | BibTeX | Altmetric)

Mabbott, Neil A.; Kobayashi, Atsushi; Sehgal, Anuj; Bradford, Barry M.; Pattison, Mari; Donaldson, David S.

Aging and the mucosal immune system in the intestine (Journal Article)

In: Biogerontology, vol. 16, no. 2, pp. 133–145, 2015, ISSN: 1389-5729, 1573-6768.

(Links | BibTeX | Altmetric)

2014

Gow, Deborah J; Sauter, Kristin A; Pridans, Clare; Moffat, Lindsey; Sehgal, Anuj; Stutchfield, Ben M; Raza, Sobia; Beard, Philippa M; Tsai, Yi Ting; Bainbridge, Graeme; Boner, Pamela L; Fici, Greg; Garcia-Tapia, David; Martin, Roger A; Oliphant, Theodore; Shelly, John A; Tiwari, Raksha; Wilson, Thomas L; Smith, Lee B; Mabbott, Neil A; Hume, David A

Characterisation of a Novel Fc Conjugate of Macrophage Colony-stimulating Factor (Journal Article)

In: Molecular Therapy, vol. 22, no. 9, pp. 1580–1592, 2014, ISSN: 15250016.

(Links | BibTeX | Altmetric)

Gow, Deborah J; Sauter, Kristin A; Pridans, Clare; Moffat, Lindsey; Sehgal, Anuj; Stutchfield, Ben M; Raza, Sobia; Beard, Philippa M; Tsai, Yi Ting; Bainbridge, Graeme; Boner, Pamela L; Fici, Greg; Garcia-Tapia, David; Martin, Roger A; Oliphant, Theodore; Shelly, John A; Tiwari, Raksha; Wilson, Thomas L; Smith, Lee B; Mabbott, Neil A; Hume, David A

Characterisation of a Novel Fc Conjugate of Macrophage Colony-stimulating Factor (Journal Article)

In: Molecular Therapy, vol. 22, no. 9, pp. 1580–1592, 2014, ISSN: 15250016.

(Links | BibTeX | Altmetric)

Sauter, Kristin A.; Pridans, Clare; Sehgal, Anuj; Bain, Calum C.; Scott, Charlotte; Moffat, Lindsey; Rojo, Rocío; Stutchfield, Ben M.; Davies, Claire L.; Donaldson, David S.; Renault, Kathleen; McColl, Barry W.; Mowat, Alan M.; Serrels, Alan; Frame, Margaret C.; Mabbott, Neil A.; Hume, David A.

The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) Provides a Novel Marker for Visualisation of Subsets of Monocytes, Macrophages and Dendritic Cells and Responsiveness to CSF1 Administration (Journal Article)

In: PLoS ONE, vol. 9, no. 8, pp. e105429, 2014, ISSN: 1932-6203.

(Links | BibTeX | Altmetric)

Sauter, Kristin A.; Pridans, Clare; Sehgal, Anuj; Bain, Calum C.; Scott, Charlotte; Moffat, Lindsey; Rojo, Rocío; Stutchfield, Ben M.; Davies, Claire L.; Donaldson, David S.; Renault, Kathleen; McColl, Barry W.; Mowat, Alan M.; Serrels, Alan; Frame, Margaret C.; Mabbott, Neil A.; Hume, David A.

The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) Provides a Novel Marker for Visualisation of Subsets of Monocytes, Macrophages and Dendritic Cells and Responsiveness to CSF1 Administration (Journal Article)

In: PLoS ONE, vol. 9, no. 8, pp. e105429, 2014, ISSN: 1932-6203.

(Links | BibTeX | Altmetric)

Sauter, K. A.; Pridans, C.; Sehgal, A.; Tsai, Y. T.; Bradford, B. M.; Raza, S.; Moffat, L.; Gow, D. J.; Beard, P. M.; Mabbott, N. A.; Smith, L. B.; Hume, D. A.

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice (Journal Article)

In: Journal of Leukocyte Biology, vol. 96, no. 2, pp. 265–274, 2014, ISSN: 0741-5400.

(Links | BibTeX | Altmetric)

Sauter, K. A.; Pridans, C.; Sehgal, A.; Tsai, Y. T.; Bradford, B. M.; Raza, S.; Moffat, L.; Gow, D. J.; Beard, P. M.; Mabbott, N. A.; Smith, L. B.; Hume, D. A.

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice (Journal Article)

In: Journal of Leukocyte Biology, vol. 96, no. 2, pp. 265–274, 2014, ISSN: 07415400, (Publisher: Federation of American Societies for Experimental Biology).

(Abstract | Links | BibTeX | Altmetric)